The X-Files

Rebecca Toolan, who plays Fox Mulder's mother, is in reality only one year older than David Duchovny.

David Duchovny originally suggested Jennifer Beals, his former classmate at Yale, for the lead female role.

In one episode, Scully tells Mulder that she thinks Téa Leoni has a crush on him, to which Mulder responds "How could Téa Leoni have a crush on me?" Téa Leoni was David Duchovny's wife in real-life at the time.