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'The Sisters Brothers' trivia and fun facts

Film Locations. Filmed in France, Spain, and Romania. Despite the film's American setting, none of the scenes were shot in the United States.
Spanish locations. The film was shot in Tabernas in Almeria, Spain. Because of its similarities to North American deserts, it previously served as filming location for a large number of Western films and series. Additional scenes were shot in Spain's northern provinces of Navarre and Aragon.
Strange Coincidences. This film features the pairing of Joaquin Phoenix and John C. Reilly. Phoenix starred as singer Johnny Cash in 'Walk the line' (2005), while Reilly starred as Dewey Cox, a character based on Johnny Cash, in Walk Hard: The Dewey Cox Story (2007).
Jake Gyllenhaal & John C. Reilly John C. Reilly and Jake Gyllenhaal previously starred in The Good Girl (2002) together, though they shared no screen time.
First english-language movie. Jacques Audiard's first English-language film.
Fonts The font used for all on-screen titles is the same font created for and used throughout the God of War (2005) series.
Jake Gyllenhaal and Riz Ahmed. This is the second collaboration between Jake Gyllenhaal and Riz Ahmed, having previously collaborated on Nightcrawler (2014).