Malcolm in the middle

Although the family's surname was revealed as Wilkerson in the pilot episode, it was decided afterwards that the family should not have a last name. A running joke on set was that the family's last name was "Nolastname."

Cloris Leachman (Grandma Ida) and Kenneth Mars (Otto Mannkusser) both use the same German accents they used in 'Young Frankenstein'.

On the show, Reese is the second oldest brother of Malcolm, but in real life, Justin Berfield (Reese) is less than three months younger than Frankie Muniz (Malcolm).