Malcolm in the middle

Although the family's surname was revealed as Wilkerson in the pilot episode, it was decided afterwards that the family should not have a last name. A running joke on set was that the family's last name was "Nolastname."

The monster seen rising from the water in the opening credits is the monster from 'Clash of the Titans'.

Aaron Paul auditioned for the role of Francis but lost. He would later be cast in 'Breaking Bad', which also starred Bryan Cranston.