Malcolm in the middle

Aaron Paul auditioned for the role of Francis but lost. He would later be cast in 'Breaking Bad', which also starred Bryan Cranston.

Cloris Leachman (Grandma Ida) and Kenneth Mars (Otto Mannkusser) both use the same German accents they used in 'Young Frankenstein'.

The monster seen rising from the water in the opening credits is the monster from 'Clash of the Titans'.