Sense8

According to Brian J. Smith, Lana (Wachowski) thinks all the main characters are pansexual.

This marks the second collaboration of Tuppence Middleton and the Wachowskis, the first being Jupiter Ascending. Doona Bae was also in Jupiter Ascending as a bounty hunter hired by Tuppence Middleton's character. Doona Bae also played multiple parts in Cloud Atlas, which makes Sense8 her third collaboration with the Wachowskis.

The 'Twin Peaks' sign seen in the opening credits is a nod to the show of the same name, where members of 'Twin Peaks', WA experience certain psychological connections following the death of Laura Palmer.