Sense8

This marks the second collaboration of Tuppence Middleton and the Wachowskis, the first being Jupiter Ascending. Doona Bae was also in Jupiter Ascending as a bounty hunter hired by Tuppence Middleton's character. Doona Bae also played multiple parts in Cloud Atlas, which makes Sense8 her third collaboration with the Wachowskis.

Many actors have actual resemblances with their characters. For example, Sun was born in Seoul and Wolfgang was born in east Germany, just like the actors.

All of the episode titles are lines from their respective episodes and are usually said by characters in the pivotal scene of the episode.