The Simpsons

According to a Simpson Family tree designed by Matt Groening, Mr. Burns is a distant relative of Homer.

This is the longest running prime-time comedy series as well as the longest-running prime-time animated series in US TV history.

Homer is the only character to have dialogue in every episode. Marge and Lisa have also appeared in every episode, but they did not deliver any dialogue in some episodes. Bart did not appear in one episode.