Lost

Andrea Gabriel (Nadia) and Lillian Hurst (Carmen Reyes) are the only performers that appear in every season but never on the island.

Originally, Michael Keaton was cast as Jack. In the first draft of the script Jack was to be killed by the monster after they arrived at the cockpit. ABC told the producers that they shouldn't kill off the hero so soon in the series and the script was changed. After the change, Michael Keaton backed out of the role since he did not want to commit to a regular series.

Jorge Garcia (Hurley) appeared on 'How I Met Your Mother' as a character named "The Blitz" who had terrible luck just like his character on 'Lost'. Then, later in the episode, someone asked him for a random phone number and he used his lottery ticket number from 'Lost' that brought him his bad luck. 4 8 15 16 23 42