Transparent

Gillian Vigman was cast as Tammy and worked on the pilot, but after Amazon picked it up for series was replaced by Melora Hardin.

Henry Simmons played Derek the trainer in the pilot episode but was replaced by Cleo Anthony when the show got picked up.

The title is a clever play on words. The word "transparent" refers to Maura's journey, letting the world see who she really is. Whereas if you break it down to "trans" and "parent", trans is short for transgender, and Maura is a transgender parent.