Transparent

Inspired by and loosely based on true events, Transparent draws themes from series creator Jill Soloway's own father coming out as a trans parent three years prior to the show's release.

Henry Simmons played Derek the trainer in the pilot episode but was replaced by Cleo Anthony when the show got picked up.

Gillian Vigman was cast as Tammy and worked on the pilot, but after Amazon picked it up for series was replaced by Melora Hardin.